Bakthadoss M, Kannan D, Srinivasan J, Vinayagam V
Department of Chemistry, Pondicherry University, Pondicherry - 605 014, India.
Org Biomol Chem. 2015 Mar 14;13(10):2870-4. doi: 10.1039/c4ob02203c.
A facile and efficient synthetic protocol was established for the construction of novel tri- and tetra-cyclic pyrrolo/pyrrolizinoquinoline architectures via the in situ formation of azomethine ylide followed by an intramolecular [3 + 2] cycloaddition reaction strategy. This protocol leads to the creation of two/three new rings and three/four contiguous stereocentres, in which one of them is a tetra-substituted carbon center, in a highly diastereoselective fashion with excellent yields.
通过原位生成甲亚胺叶立德，然后采用分子内[3 + 2]环加成反应策略，建立了一种简便高效的合成方法，用于构建新型的三环和四环吡咯/吡咯里西诺喹啉结构。该方法以高非对映选择性和优异产率生成两个/三个新环和三个/四个相邻的立体中心，其中一个是四取代的碳中心。
