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环状醚和硫醚的多米诺开环反应及选择性O/S-烷基化反应。

Domino ring opening and selective O/S-alkylation of cyclic ethers and thioethers.

作者信息

Bakthadoss Manickam, Agarwal Vishal, Tadiparthi Thirupathi Reddy, Mohammad Mushaf

机构信息

Department of Chemistry, Pondicherry University, Pondicherry, 605 014, India.

出版信息

Mol Divers. 2021 Nov;25(4):2467-2478. doi: 10.1007/s11030-020-10105-2. Epub 2020 May 27.

DOI:10.1007/s11030-020-10105-2
PMID:32462464
Abstract

Chemoselective domino ring opening and selective O/S-alkylation of ethers/thioethers over enol C/O alkylation has been observed. Various 2-aryl chromanones/thiochromanones with alkyl/allyl bromides were smoothly converted into the corresponding highly functionalized ethers and thioethers in excellent yields with high selectivity. An unusual, chemoselective domino ring opening and selective ether/thioether O/S-alkylation over. An unusual, chemoselective domino ring opening and selective ether/thioether O/S alkylation over enol C/O alkylation has been observed.

摘要

已观察到在烯醇C/O烷基化反应中，醚/硫醚的化学选择性多米诺开环反应以及选择性O/S-烷基化反应。各种2-芳基色满酮/硫色满酮与烷基/烯丙基溴顺利反应，以优异的产率和高选择性转化为相应的高度官能化的醚和硫醚。一种不寻常的、化学选择性的多米诺开环反应以及在烯醇C/O烷基化反应之上的选择性醚/硫醚O/S-烷基化反应。已观察到一种不寻常的、化学选择性的多米诺开环反应以及在烯醇C/O烷基化反应之上的选择性醚/硫醚O/S烷基化反应。

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