Santolaya M E, Henríquez A, Latorre J J
Rev Chil Pediatr. 1989 May-Jun;60(3):147-50.
Adenoviruses are well known and ubiquitous causes of respiratory illness in children. Serious long-term sequelae and even fatalities have been described in young children affected by adenoviral infections of the respiratory tract. This is a report on clinical and histopathological features of 25 infants dying from acute lower respiratory tract infections apparently caused by adenoviruses, from January 1st 1983 through December 31st 1986. The diagnosis was based on the finding of distinctive intranuclear inclusions in the pulmonary lesions that were present in all 25 cases at necropsy. Necrotizing bronchiolitis was found in 24 patients (96%). Nineteen patients (76%) were younger than 1 year of age and 15 (60%) had underlying malnutrition. In 17 instances (68%) the respiratory illness was nosocomial in origin. A specific etiologic diagnosis was not made in any of the 25 patients during the course of the illness, twenty four of them (96%) received various antimicrobial drugs without success.
腺病毒是引起儿童呼吸道疾病的常见且普遍存在的病原体。已有报道称，受呼吸道腺病毒感染的幼儿会出现严重的长期后遗症甚至死亡。本文报告了1983年1月1日至1986年12月31日期间25例因明显由腺病毒引起的急性下呼吸道感染而死亡的婴儿的临床和组织病理学特征。诊断依据是尸检时在所有25例病例的肺部病变中发现独特的核内包涵体。24例患者（96%）发现有坏死性细支气管炎。19例患者（76%）年龄小于1岁，15例（60%）有潜在营养不良。17例（68%）的呼吸道疾病起源于医院感染。25例患者在患病过程中均未做出特异性病因诊断，其中24例（96%）接受了各种抗菌药物治疗但均未成功。
