淋巴结微环境及其在转移性癌症进展中的作用。
The lymph node microenvironment and its role in the progression of metastatic cancer.
作者信息
Pereira Ethel R, Jones Dennis, Jung Keehoon, Padera Timothy P
机构信息
E.L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
E.L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114, USA.
出版信息
Semin Cell Dev Biol. 2015 Feb;38:98-105. doi: 10.1016/j.semcdb.2015.01.008. Epub 2015 Jan 22.
Abstract
Lymph nodes are initial sites for cancer metastasis in many solid tumors. However, their role in cancer progression is still not completely understood. Emerging evidence suggests that the lymph node microenvironment provides hospitable soil for the seeding and proliferation of cancer cells. Resident immune and stromal cells in the lymph node express and secrete molecules that may facilitate the survival of cancer cells in this organ. More comprehensive studies are warranted to fully understand the importance of the lymph node in tumor progression. Here, we will review the current knowledge of the role of the lymph node microenvironment in metastatic progression.
摘要
淋巴结是许多实体瘤发生癌症转移的初始部位。然而，它们在癌症进展中的作用仍未被完全理解。新出现的证据表明，淋巴结微环境为癌细胞的播种和增殖提供了适宜的土壤。淋巴结中的常驻免疫细胞和基质细胞表达并分泌可能促进癌细胞在该器官中存活的分子。需要进行更全面的研究以充分了解淋巴结在肿瘤进展中的重要性。在此，我们将综述目前关于淋巴结微环境在转移进展中作用的知识。
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