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在“全喉切除伴部分咽切除”病例中,双层咽黏膜修复与常规单层修复相比对咽皮肤瘘形成的比较研究

Comparative Study Between Double Layered Repair of Pharyngeal Mucosa Against Routine Single Layered Repair in Cases of "Total Laryngectomy with Partial Pharyngectomy" in Respect To Formation of Pharyngo-cutaneous Fistula.

作者信息

Shukla Anirudh, Dudeja Vivek

机构信息

Department of Otorhinolaryngology and Head Neck Surgery, Netaji Subhash Chandra Bose Medical College and Hospital, Jabalpur, India ; H.No. 1349, Home Science College Road, Napier Town, Jabalpur, 482002 Madhya Pradesh India.

Department of Otorhinolaryngology and Head Neck Surgery, Netaji Subhash Chandra Bose Medical College and Hospital, Jabalpur, India ; H.No. 104, H.I.G Dhanwantry Nagar, Near Medical College, Jabalpur, Madhya Pradesh India ; H.No. 1336, Sector-13, Near Community Centre, Hisar, Haryana 125005 India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2015 Mar;67(Suppl 1):8-11. doi: 10.1007/s12070-014-0704-8. Epub 2014 Feb 1.

Abstract

Advanced glottic cancer (T3,N+ & T4) is usually treated in the majority of centres by total laryngectomy. Carcinoma of the larynx is one of the very few subsets of all cancers which have shown a decrease in the 5 year survival rate and this phenomenon has been attributed to a Pharyngo-cutaneous fistula is the most common complication after total laryngectomy. Comparative study between double layered repair of pharyngeal mucosa against routine single layered repair in cases of "total laryngectomy with partial pharyngectomy". All patients with the principal procedure of "total laryngectomy with partial pharyngectomy" in department of otorhinolaryngology and head-neck surgery, Netaji Subhash Chandra Bose Medical College, Jabalpur, Madhya Pradesh, India were included in this study. Out of the 20 patients who had undergone total laryngectomy irrespective of the type of mucosal repair, 5 (25 %) patients developed pharyngocutaneous fistula. Out of the 8 patients, with double layered mucosa repair, 1 (12.5 %) patient developed pharyngocutaneous fistula. Out of the 12 patients, with single layered mucosa repair, 4 (33 %) patients developed pharyngocutaneous fistula. Double layered repair of pharyngeal mucosa is associated with a lower incidence of pharyngocutaneous fistula formation and no increased incidence of dysphagia after complete radiotherapy as compared to single layered repair.

摘要

晚期声门癌(T3、N+和T4)在大多数中心通常采用全喉切除术治疗。喉癌是所有癌症中极少数5年生存率出现下降的亚组之一,这种现象归因于咽皮肤瘘是全喉切除术后最常见的并发症。在“全喉切除联合部分咽切除术”病例中,对咽黏膜双层修复与常规单层修复进行比较研究。印度中央邦贾巴尔普尔市Netaji Subhash Chandra Bose医学院耳鼻喉头颈外科所有接受“全喉切除联合部分咽切除术”主要手术的患者均纳入本研究。在20例接受全喉切除术的患者中,无论黏膜修复类型如何,有5例(25%)患者发生了咽皮肤瘘。在8例采用双层黏膜修复的患者中,有1例(12.5%)患者发生了咽皮肤瘘。在12例采用单层黏膜修复的患者中,有4例(33%)患者发生了咽皮肤瘘。与单层修复相比,咽黏膜双层修复与咽皮肤瘘形成的发生率较低相关,并且在完全放疗后吞咽困难的发生率没有增加。

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