Mikheyev Alexander S, Linksvayer Timothy A
Ecology and Evolution Unit, Okinawa Institute of Science and Technology, Okinawa, Japan.
Department of Biology, University of Pennsylvania, Philadelphia, United States.
Elife. 2015 Jan 26;4:e04775. doi: 10.7554/eLife.04775.
Studies of the genetic basis and evolution of complex social behavior emphasize either conserved or novel genes. To begin to reconcile these perspectives, we studied how the evolutionary conservation of genes associated with social behavior depends on regulatory context, and whether genes associated with social behavior exist in distinct regulatory and evolutionary contexts. We identified modules of co-expressed genes associated with age-based division of labor between nurses and foragers in the ant Monomorium pharaonis, and we studied the relationship between molecular evolution, connectivity, and expression. Highly connected and expressed genes were more evolutionarily conserved, as expected. However, compared to the rest of the genome, forager-upregulated genes were much more highly connected and conserved, while nurse-upregulated genes were less connected and more evolutionarily labile. Our results indicate that the genetic architecture of social behavior includes both highly connected and conserved components as well as loosely connected and evolutionarily labile components.
对复杂社会行为的遗传基础和进化的研究，要么强调保守基因，要么强调新基因。为了开始调和这些观点，我们研究了与社会行为相关的基因的进化保守性如何依赖于调控背景，以及与社会行为相关的基因是否存在于不同的调控和进化背景中。我们在法老小家蚁中鉴定出了与基于年龄的护士蚁和觅食蚁分工相关的共表达基因模块，并研究了分子进化、连通性和表达之间的关系。正如预期的那样，高度连通和表达的基因在进化上更保守。然而，与基因组的其他部分相比，觅食蚁上调的基因连通性更高且更保守，而护士蚁上调的基因连通性较低且在进化上更不稳定。我们的结果表明，社会行为的遗传结构既包括高度连通和保守的成分，也包括松散连通和进化上不稳定的成分。
Zotero 插件
