J Invest Dermatol. 1966 Aug;47(1):22-6.
Exploratory studies on topical administration of 20% 5-Fluorouracil in hydrophilic base were carried out in 36 solitary nodular basal cell carcinomas. Under the conditions of this study, tumor resolution lasting through an observation period of 20 months was observed in 21 study sites, although changes in the natural course of lesions were present in all the tumors. Topical administration of anti-tumor agents is not suitable for clinical management of solitary basal cell carcinoma at the present. Further evaluation as an investigative approach in studies on chemotherapy and tumor biology may be warranted.
在 36 例孤立性结节状基底细胞瘤中进行了 20% 5-氟尿嘧啶亲水基质局部给药的探索性研究。在本研究条件下，尽管所有肿瘤均存在病变自然病程的变化，但在 21 个研究部位观察到持续 20 个月的肿瘤消退。目前，局部应用抗肿瘤药物并不适合临床治疗孤立性基底细胞瘤。作为化疗和肿瘤生物学研究的一种探索性方法，进一步评估可能是有必要的。
