Epstein E H, Epstein W L
Department of Medicine, University of California, San Francisco, USA.
J Invest Dermatol. 1966 May;46(5):453-8.
Intradermal injection of thymidine-H3 fol- lowed by biopsy removal 40 minutes to 36 days later revealed a characteristic pattern of human sebaceous gland activity. Cells lying on or near the basement membrane divide, and daughter cells move centrally, produce lipid, and undergo nuclear degeneration. The steady state replenishment from the periphery con- tinues for at least 2 to 4 weeks. The average renewal time for the human sebaceous gland in the 4 specimens examined is 7.4 days.
皮内注射胸腺嘧啶核苷-H3，40分钟至36天后进行活检切除，结果显示了人皮脂腺活动的特征模式。位于基底膜上或其附近的细胞分裂，子细胞向中央移动，产生脂质，并经历核变性。从周边进行的稳态补充至少持续2至4周。在所检查的4个标本中，人皮脂腺的平均更新时间为7.4天。
