Strippoli V, Piacentini A, D'Auria F D, Simonetti N
Institute of Microbiology, Faculty of Medicine and Surgery, Rome, Italy.
Infection. 1997 Sep-Oct;25(5):303-6. doi: 10.1007/BF01720401.
The in vitro activity of several antifungal agents (ketoconazole, miconazole, econazole, fenticonazole, itraconazole, fluconazole) in routine clinical use against Malassezia furfur infections has been studied with freshly isolated strains of M. furfur from pityriasis versicolor lesions. The results indicate that the drugs tested exert a good activity, and both ketoconazole and itraconazole appear very active (0.8 mg/l respectively). Hair samples from the beards of volunteer patients affected by pityriasis versicolor but otherwise healthy were examined to determine ketoconazole levels during oral therapy (one or two 200 mg tablets daily). It was shown that the drug progressively accumulates in the beard, reaching levels proportional to the dose administered, although blood levels did not increase in parallel. The study of drug concentration profile has evidenced a long ketoconazole persistence in the beard at therapeutic levels. In conclusion, the possibility of reaching high and lasting ketoconazole levels in the keratin layer of the epidermis indicates that systemic ketoconazole therapy could be useful for eradication of M. furfur in patients affected by pityriasis versicolor.
已使用从花斑癣皮损处新分离的糠秕马拉色菌菌株，研究了几种临床常用抗真菌药物（酮康唑、咪康唑、益康唑、芬替康唑、伊曲康唑、氟康唑）对糠秕马拉色菌感染的体外活性。结果表明，所测试的药物具有良好的活性，酮康唑和伊曲康唑似乎活性非常高（分别为0.8毫克/升）。对患有花斑癣但其他方面健康的志愿者患者的胡须毛发样本进行了检查，以确定口服治疗（每日一或两片200毫克片剂）期间的酮康唑水平。结果显示，药物在胡须中逐渐蓄积，达到与给药剂量成比例的水平，尽管血药浓度并未平行升高。药物浓度分布研究证明，酮康唑在治疗水平下在胡须中持续存在的时间很长。总之，在表皮角质层中达到高且持久的酮康唑水平的可能性表明，全身性酮康唑治疗可能有助于根除花斑癣患者体内的糠秕马拉色菌。
