Li Yilei, Wang Ying, Liu Xinyuan, Guo Hao, Wang Zheng, Zhai Ning, Li Jiuhong
Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China.
Department of Dermatology, First Affiliated Hospital, China Medical University, Shenyang 110001, China. Email:
Zhonghua Yi Xue Za Zhi. 2014 Dec 16;94(46):3652-4.
To explore the relationship between vascular endothelial growth factor (VEGF) and the onset of psoriasis.
The intensity and site expression of VEGF in 34 psoriatic lesions and skin samples of 21 normal controls were observed by immunohistochemistory from December 2011 to May 2013. And the serum levels of VEGF in 70 psoriasis vulgaris and 39 normal controls were measured by enzyme-linked immunosorbent assay (ELISA).
The expression of VEGF in psoriatic lesions was much higher than that in normal controls (χ(2) = 13.34, P < 0.01) . The serum level of VEGF in psoriasis vulgaris was higher than that in normal controls ( (501 ± 13) vs (413 ± 5) ng/L, t = 2.32, P < 0.01). The serum level of VEGF in psoriasis vulgaris with PASI score >10 was higher than that with PASI score ≤ 10 ( (530 ± 18) vs (451 ± 8) ng/L, t = 2.18, P < 0.01).
VEGF may play a role in the pathogenesis of psoriasis.
探讨血管内皮生长因子（VEGF）与银屑病发病的关系。
2011年12月至2013年5月，采用免疫组织化学方法观察34例银屑病皮损及21例正常对照皮肤样本中VEGF的表达强度及部位。采用酶联免疫吸附测定（ELISA）法检测70例寻常型银屑病患者和39例正常对照者血清中VEGF水平。
银屑病皮损中VEGF的表达明显高于正常对照（χ(2)=13.34，P<0.01）。寻常型银屑病患者血清VEGF水平高于正常对照（（501±13）对（413±5）ng/L，t=2.32，P<0.01）。银屑病面积和严重程度指数（PASI）评分>10的寻常型银屑病患者血清VEGF水平高于PASI评分≤10的患者（（530±18）对（451±8）ng/L，t=2.18，P<0.01）。
VEGF可能在银屑病发病机制中起作用。
