Kuhre Rune Ehrenreich, Wewer Albrechtsen Nicolai Jacob, Hartmann Bolette, Deacon Carolyn F, Holst Jens Juul
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, DK-2200 Copenhagen, Denmark; Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, DK-2200 Copenhagen, Denmark.
J Diabetes Complications. 2015 Apr;29(3):445-50. doi: 10.1016/j.jdiacomp.2014.12.006. Epub 2014 Dec 15.
The two incretin hormones, glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP), are secreted from the gastrointestinal tract in response to meals and contribute to the regulation of glucose homeostasis by increasing insulin secretion. Assessment of plasma concentrations of GLP-1 and GIP is often an important endpoint in both clinical and preclinical studies and, therefore, accurate measurement of these hormones is important. Here, we provide an overview of current approaches for the measurement of the incretin hormones, with particular focus on immunological methods.
两种肠促胰岛素激素，即胰高血糖素样肽1（GLP-1）和葡萄糖依赖性促胰岛素多肽（GIP），会在进食后从胃肠道分泌出来，并通过增加胰岛素分泌来调节葡萄糖稳态。在临床和临床前研究中，评估血浆中GLP-1和GIP的浓度通常是一个重要的终点指标，因此，准确测量这些激素很重要。在此，我们概述了目前测量肠促胰岛素激素的方法，特别关注免疫学法。
