Bonfante Ivan Luiz Padilha, Duft Renata Garbellini, Mateus Keryma Chaves da Silva, Trombeta Joice Cristina Dos Santos, Chacon-Mikahil Mara Patricia Traina, Velloso Licio Augusto, Cavaglieri Cláudia Regina
Laboratory of Exercise Physiology, Faculty of Physical Education, University of Campinas, Campinas, Brazil.
Federal Institute of Education, Science and Technology of São Paulo, Hortolândia Campus, Hortolândia, Brazil.
Eur J Sport Sci. 2024 Jan;24(1):97-106. doi: 10.1002/ejsc.12057.
The incretins (glucose-dependent insulinotropic polypeptide [GIP] and glucagon-like peptide-1 [GLP-1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin-degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase-4 (DPP-4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP-1, GIP, DPP-4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP-1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP-1 (-9.3%; p = 0.03) and amylin/IAPP (-13.4%; p < 0.01), in addition to an increase for DPP-4 (6.2%; p = 0.04) enzyme. CT decreases the baseline levels of important hormones with insulinotropic actions in individuals with T2DM and overweight. The improvement in overall metabolism provided by CT must be the main reason for these effects. These results broaden the understanding of the effects and relationships between CT and glucose metabolism.
肠促胰岛素（葡萄糖依赖性促胰岛素多肽[GIP]和胰高血糖素样肽-1[GLP-1]），以及胰淀素/胰岛淀粉样多肽（IAPP）和胰岛素降解酶（IDE），是因其促胰岛素作用而成为药理学靶点的激素/酶，如二肽基肽酶-4（DPP-4）抑制剂。体育锻炼被推荐作为2型糖尿病（T2DM）的一种治疗方法；然而，其对这些激素/酶浓度的影响尚不清楚。因此，本研究旨在评估联合训练（CT）对T2DM和超重个体中具有促胰岛素作用的激素/酶浓度的影响。患有T2DM的男女个体（年龄51.73±4.19岁；体重指数[BMI]29.46±3.39kg/m）被随机分为对照组（CG，n=17）和联合训练组（CTG，n=17）。CT包括力量训练后进行有氧训练，每周3次，共16周。评估了功能变量、身体成分和血清生化分析（临床指标、GLP-1、GIP、DPP-4、胰淀素/IAPP和IDE）。在组/时间分析中，CTG组的GLP-1降低（训练前：32.8±12.1，训练后：28.4±13.5，p=0.04）。在评估变化的Δ%时，CTG组的GLP-1降低（-9.3%；p=0.03），胰淀素/IAPP降低（-13.4%；p<0.01），此外DPP-4酶增加（6.2%；p=0.04）。CT降低了T2DM和超重个体中具有促胰岛素作用的重要激素的基线水平。CT带来的整体代谢改善必定是这些影响的主要原因。这些结果拓宽了对CT与葡萄糖代谢之间的影响及关系的理解。
