头颈部鳞状细胞癌的免疫疗法
Immunotherapy for head and neck squamous cell carcinoma.
作者信息
Li Qiao, Prince Mark E P, Moyer Jeffrey S
机构信息
University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Dr., Ann Arbor, MI 48109, United States.
University of Michigan Comprehensive Cancer Center, 1500 E Medical Center Dr., Ann Arbor, MI 48109, United States.
出版信息
Oral Oncol. 2015 Apr;51(4):299-304. doi: 10.1016/j.oraloncology.2014.12.005. Epub 2015 Jan 24.
OBJECTIVES
To review the current state of immunotherapy of head and neck squamous cell carcinoma.
MATERIALS AND METHODS
Review of the literature with emphasis on clinical trial data.
RESULTS
Patients with head and neck squamous cell carcinoma (HNSCC) have long been known to be immunosuppressed. This impairment of the immune system is believed, at least in part, to underlie the poor outcomes in this patient population. Modulating the immune system to improve cancer outcomes is an attractive concept in this difficult to treat population.
CONCLUSION
New studies have started to unravel the mechanisms of immunosuppression and new therapies are being developed to exploit this new information.
目的
回顾头颈部鳞状细胞癌免疫治疗的现状。
材料与方法
回顾文献，重点关注临床试验数据。
结果
长期以来已知头颈部鳞状细胞癌（HNSCC）患者存在免疫抑制。免疫系统的这种损害至少在一定程度上被认为是该患者群体预后不良的原因。在这个难以治疗的群体中，调节免疫系统以改善癌症预后是一个有吸引力的概念。
结论
新的研究已开始揭示免疫抑制的机制，并且正在开发新的疗法以利用这些新信息。
Zotero 插件