Resser J R, Carbone D P
Vanderbilt Bill Wilkerson Center for Otolaryngology and Communicative Sciences, Vanderbilt University Medical Center, Nashville, TN, USA.
Curr Opin Oncol. 1998 May;10(3):226-32. doi: 10.1097/00001622-199805000-00009.
Despite advances in surgical chemotherapeutic and radiotherapeutic techniques, the overall cure rates for head and neck cancer have been disappointing. There is experimental and clinical evidence that deficiencies in the immune system play an important role in the initiation and propagation of cancer. Several strategies have been investigated to try to correct these deficiencies and also to improve the immune response. This article reviews proposed mechanisms of immunosuppression, techniques in nonspecific immunotherapy, use of tumor-infiltrating and cytokine-activated lymphocytes, discoveries and potential uses of tumor antigens, and advances in immunogene therapy in head and neck cancer. These mechanisms of immunotherapy may become an important modality in the treatment of head and neck cancer.
尽管手术、化疗和放疗技术取得了进展，但头颈癌的总体治愈率仍不尽人意。有实验和临床证据表明，免疫系统缺陷在癌症的发生和发展中起重要作用。人们已经研究了几种策略来纠正这些缺陷并改善免疫反应。本文综述了免疫抑制的潜在机制、非特异性免疫治疗技术、肿瘤浸润淋巴细胞和细胞因子激活淋巴细胞的应用、肿瘤抗原的发现和潜在用途，以及头颈癌免疫基因治疗的进展。这些免疫治疗机制可能成为头颈癌治疗的重要方式。
