Lachocki T M, Nuggehalli S K, Scherer K V, Church D F, Pryor W A
Biodynamics Institute, Louisiana State University, Baton Rouge 70803.
Chem Res Toxicol. 1989 May-Jun;2(3):174-80. doi: 10.1021/tx00009a009.
Spin adducts are observed when the unfiltered smoke produced during the aerobic pyrolysis of perfluoro polymers (PFP) is bubbled through a solution of the ESR spin trap alpha-phenyl-N-tert-butylnitrone (PBN). The spin adducts include those from an oxy radical and the fluorine atom, and in addition the spin trap is oxidized to PBNOx. The spin adduct of a chlorine atom also is observed, presumably because of chlorine-containing impurities in the polymers. Tetrafluoroethylene is produced during the pyrolysis of PFP; therefore, we subjected tetrafluoroethylene to the same pyrolysis as was used for PFP, and we observe the same series of spin adducts. We suggest that the spin adducts formed from the whole, unfiltered smoke from PFP smoke may result both from free radicals that form during the pyrolysis of PFP and from the oligomerization of the tetrafluoroethylene produced during the pyrolysis. These spin-trapping results support the theory that reactive free radicals are present in PFP smoke and may contribute to PFP smoke toxicity.
当全氟聚合物（PFP）有氧热解过程中产生的未过滤烟雾鼓泡通过电子自旋共振（ESR）自旋捕捉剂α-苯基-N-叔丁基硝酮（PBN）溶液时，会观察到自旋加合物。自旋加合物包括来自氧自由基和氟原子的加合物，此外，自旋捕捉剂被氧化为PBNOx。还观察到了氯原子的自旋加合物，推测这是由于聚合物中含氯杂质所致。PFP热解过程中会产生四氟乙烯；因此，我们让四氟乙烯经历与PFP相同的热解过程，并且观察到了相同系列的自旋加合物。我们认为，由PFP烟雾的完整未过滤烟雾形成的自旋加合物可能既源于PFP热解过程中形成的自由基，也源于热解过程中产生的四氟乙烯的低聚反应。这些自旋捕捉结果支持了这样一种理论，即PFP烟雾中存在反应性自由基，并且可能导致PFP烟雾的毒性。
