Yang K C, Li X, Tsui Z C
Department of Biochemistry, Dalian Medical College, China.
In Vivo. 1989 May-Jun;3(3):211-4.
A new parameter, the ratio of lipid peroxide and vitamins E and C [LPO/(VE + VC)], has been proposed and used to reflect the balance between lipid peroxidation and antioxidation capability of cancer patients and of healthy human controls. The effects of vitamins E, C, and selenium on the serum LPO level in mice bearing Ascites Hepatomas (H22) have also been examined. The results showed that the average of LPO/(VE + VC) ratios in cancer patients (135 cases) was significantly higher than that of the normal controls (222 cases). The authors suggest that this ratio might be used as one of the parameters for early diagnosis and prognosis of diseases (including cancers) caused by free radicals and lipid peroxides. The results also showed that antioxidants - Se(Na2SeO3, 1mg/kg) or vitamin E (5mg/kg) could markedly decrease the level of serum LPO in the tumor-bearing animals. A smaller dose of VE (1mg/kg) and doses of Vc up to 300mg/kg showed no effect on the serum LPO levels when given separately. However, synergistic effects were observed when any 2 out of 3 or three nutrients were given together. Those with three nutrients significantly lowered the serum LPO level. These antioxidants also inhibited the proliferation of tumour cells.
一个新的参数，即脂质过氧化物与维生素E和C的比值[LPO/(VE + VC)]，已被提出并用于反映癌症患者及健康人体对照的脂质过氧化与抗氧化能力之间的平衡。同时也研究了维生素E、C和硒对荷腹水型肝癌（H22）小鼠血清LPO水平的影响。结果显示，癌症患者（135例）的LPO/(VE + VC)比值平均值显著高于正常对照（222例）。作者认为该比值可作为由自由基和脂质过氧化物引起的疾病（包括癌症）早期诊断和预后的参数之一。结果还表明，抗氧化剂——硒（亚硒酸钠，1mg/kg）或维生素E（5mg/kg）可显著降低荷瘤动物的血清LPO水平。单独给予较小剂量的VE（1mg/kg）和高达300mg/kg的VC剂量时，对血清LPO水平无影响。然而，当三种营养素中的任意两种同时给予时，观察到协同作用。三种营养素同时给予时可显著降低血清LPO水平。这些抗氧化剂还能抑制肿瘤细胞的增殖。
