Efunshile Akinwale Michael, Olawale Temitope, Stensvold Christen Rune, Kurtzhals Jørgen A L, König Brigitte
Institute of Medical Microbiology and Infectious Disease Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany; Federal Teaching Hospital, Abakaliki, Nigeria; Department of Medical Microbiology and Parasitology, University of Lagos, Lagos, Nigeria; Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark; Centre for Medical Parasitology, Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark; Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark
Institute of Medical Microbiology and Infectious Disease Epidemiology, Medical Faculty, University of Leipzig, Leipzig, Germany; Federal Teaching Hospital, Abakaliki, Nigeria; Department of Medical Microbiology and Parasitology, University of Lagos, Lagos, Nigeria; Department of Microbiology and Infection Control, Statens Serum Institut, Copenhagen, Denmark; Centre for Medical Parasitology, Department of Clinical Microbiology, Copenhagen University Hospital, Copenhagen, Denmark; Department of International Health, Immunology, and Microbiology, University of Copenhagen, Copenhagen, Denmark.
Am J Trop Med Hyg. 2015 Mar;92(3):578-82. doi: 10.4269/ajtmh.14-0548. Epub 2015 Jan 26.
The relationship between intestinal helminth infection and susceptibility to malaria remains unclear. We studied the relationship between these infections. Seven schools in Ilero, Nigeria referred all pupils with febrile illness to our study center for free malaria treatment during a 3-month study period. At the end, all pupils submitted a stool sample for microscopic investigation for helminth eggs. We used an unmatched case-control design to calculate the odds ratios for helminth infection in children with at least one attack of malaria (cases) and children with no malaria episodes during the study (controls). We recorded 115 malaria cases in 82 of 354 (23.2%), 16 of 736 (2.2%), and 17 of 348 (4.7%) children ages ≤ 5, 6-10, and 11-15 years old, respectively (P = 0.001). Helminth infection rate in cases was 21 of 115 (18.3%) compared with 456 of 1,327 (34.4%) in controls. Weighted odds ratio stratified by age group for helminth infection in cases versus controls was 0.50 (95% confidence interval = 0.2-0.84, P < 0.01). Ascaris and hookworm were the most common helminths detected, with prevalence rates of 14 (12.2%) and 6 (5.2%) among cases compared with 333 (25.1%) and 132 (10.0%) in controls, respectively (P = 0.001). The negative association between helminth infection and malaria may be of importance in the design of deworming programs.
肠道蠕虫感染与疟疾易感性之间的关系仍不清楚。我们研究了这些感染之间的关系。在尼日利亚伊莱罗的七所学校，在为期3个月的研究期间，将所有发热疾病的学生转介到我们的研究中心接受免费疟疾治疗。最后，所有学生都提交了粪便样本进行显微镜检查以查找蠕虫卵。我们采用非匹配病例对照设计来计算至少有一次疟疾发作的儿童（病例）和研究期间无疟疾发作的儿童（对照）中蠕虫感染的比值比。我们分别记录了354名5岁及以下儿童中的82名（23.2%）、736名6 - 10岁儿童中的16名（2.2%）和348名11 - 15岁儿童中的17名（4.7%）患疟疾情况（P = 0.001）。病例组中蠕虫感染率为115例中的21例（18.3%），而对照组为1327例中的456例（34.4%）。按年龄组分层的病例与对照中蠕虫感染的加权比值比为0.50（95%置信区间 = 0.2 - 0.84，P < 0.01）。蛔虫和钩虫是检测到的最常见蠕虫，病例组中的患病率分别为14例（12.2%）和6例（5.2%），而对照组分别为333例（25.1%）和132例（10.0%）（P = 0.001）。蠕虫感染与疟疾之间的负相关关系在驱虫计划的设计中可能具有重要意义。
