Gajbhiye Snehlata V, Jadhav Kshitij S, Marathe Padmaja A, Pawar Dattatray B
Departments of Pharmacology and Therapeutics, Seth Gordhandas Sundardas Medical College and King Edward Memorial Hospital, Parel, Mumbai, Maharashtra, India.
Indian J Urol. 2015 Jan-Mar;31(1):15-21. doi: 10.4103/0970-1591.128496.
Animal models have contributed to a great extent to understanding and advancement in the field of sexual medicine. Many current medical and surgical therapies in sexual medicine have been tried based on these animal models. Extensive literature search revealed that the compiled information is limited. In this review, we describe various experimental models of erectile dysfunction (ED) encompassing their procedures, variables of assessment, advantages and disadvantages. The search strategy consisted of review of PubMed based articles. We included original research work and certain review articles available in PubMed database. The search terms used were "ED and experimental models," "ED and nervous stimulation," "ED and cavernous nerve stimulation," "ED and central stimulation," "ED and diabetes mellitus," "ED and ageing," "ED and hypercholesteremia," "ED and Peyronie's disease," "radiation induced ED," "telemetric recording," "ED and mating test" and "ED and non-contact erection test."
动物模型在很大程度上促进了性医学领域的理解与发展。性医学领域目前的许多药物和手术疗法都是基于这些动物模型进行试验的。广泛的文献检索表明，所收集的信息有限。在本综述中，我们描述了勃起功能障碍（ED）的各种实验模型，包括其操作过程、评估变量、优缺点。检索策略包括对基于PubMed的文章进行综述。我们纳入了PubMed数据库中可用的原始研究工作和某些综述文章。所使用的检索词为“ED与实验模型”、“ED与神经刺激”、“ED与海绵体神经刺激”、“ED与中枢刺激”、“ED与糖尿病”、“ED与衰老”、“ED与高胆固醇血症”、“ED与佩罗尼氏病”、“辐射诱导的ED”、“遥测记录”、“ED与交配试验”以及“ED与非接触勃起试验”。
