Department of Urology, University of Washington School of Medicine, Seattle, Washington, USA.
J Urol. 2009 Dec;182(6 Suppl):S45-50. doi: 10.1016/j.juro.2009.07.089.
We provide an overview of basic, clinical and epidemiological research in the field of erectile dysfunction and important research priorities presented at the 2009 National Institute of Diabetes and Digestive and Kidney Diseases symposium on Urological Complications of Diabetes and Obesity.
Experts in molecular biology, physiology, pharmacology, clinical trials, epidemiology and urological surgery highlighted current knowledge on erectile dysfunction associated with diabetes mellitus and obesity.
Predictable associations between erectile dysfunction, and poor diabetic control and modifiable risk factors, including body mass index, have not yet been translated into randomized trials in the United States. The relationship between erectile dysfunction and metabolic syndrome, and surrogate markers for erectile dysfunction requires further investigation. Basic research aimed at discovering disease mechanisms and therapeutic targets has focused on autonomic neuropathy, vascular dysfunction, smooth muscle contractile function and matrix. However, significant gaps exist in regard to the integration of molecular, cellular and functional data. Animal models of type 2 diabetes and obesity associated erectile dysfunction require investigation because most basic science studies have used rodent models of type 1 diabetes.
Studies are needed to synthesize a systems biology understanding of erectile function/dysfunction, and characterize and disseminate rodent models of erectile dysfunction associated with type 2 diabetes and obesity. Clinical studies are needed of promising intervention and prevention strategies. Leveraging existing and future cohort phenotypes, and biological samples is needed for risk factor analysis, biomarker discovery and genome wide association studies.
我们提供了一个概述的基础上，临床和流行病学研究领域的勃起功能障碍和重要的研究重点在 2009 年国立糖尿病、消化和肾脏疾病研究所的研讨会对泌尿科并发症的糖尿病和肥胖。
专家在分子生物学，生理学，药理学，临床试验，流行病学和泌尿科手术强调目前的知识与勃起功能障碍相关的糖尿病和肥胖。
可预测的协会与勃起功能障碍，和较差的糖尿病控制和可改变的危险因素，包括体重指数，还没有被翻译成随机试验在美国。勃起功能障碍与代谢综合征之间的关系，和勃起功能障碍的替代指标需要进一步研究。基础研究旨在发现疾病的机制和治疗靶点的重点放在自主神经病变，血管功能障碍，平滑肌收缩功能和基质。然而，存在显著差距方面的整合分子，细胞和功能数据。动物模型的 2 型糖尿病和肥胖相关的勃起功能障碍需要研究，因为大多数基础科学研究已经使用了啮齿类动物模型 1 型糖尿病。
需要研究来综合系统生物学的理解勃起功能/障碍，并描述和传播的啮齿类动物模型的勃起功能障碍与 2 型糖尿病和肥胖。临床研究需要有前途的干预和预防策略。利用现有的和未来的队列表型和生物样本进行危险因素分析，生物标志物的发现和全基因组关联研究。
