Sunba M S, al-Ali S Y
Eye Department, Ibn Sina Hospital, Safat, Kuwait.
Histol Histopathol. 1989 Jul;4(3):257-64.
The present study describes for the first time, the clinical, light and electron microscopic findings of two cases of conjunctival rhinosporidiosis. One was with concurrent infection of papillomavirus. Investigations at the ultrastructural level have provided additional information on the development of Rhinosporidium seeberi and would suggest that the formation of the wall of this organism is a continuous morphological and biochemical spectrum throughout its cytological maturation. The current observation on the wall formation is probably a modification of the classical pattern as an environmental protection carried out by the fungus against the virus. In contradistinction to the usual histopathological picture of rhinosporidiosis, the case with the viral infection lacked the characteristic marked inflammatory reaction. This finding, together with the relatively short interval of the frequent recurrences of this lesion, have led us to postulate the presence of a localised acquired immune deficiency state. It is possible that this local immune deficiency may be caused by an immunosuppression mechanism. This is probably mediated by papillomavirus and/or due to the weak antigenicity of the host virus-infected cells which contain only copies of viral DNA in an unintegrated form.
本研究首次描述了两例结膜鼻孢子虫病的临床、光学和电子显微镜检查结果。其中一例合并乳头瘤病毒感染。超微结构水平的研究为西伯鼻孢子虫的发育提供了更多信息，并表明该生物体壁的形成在其细胞学成熟过程中是一个连续的形态和生化过程。目前对壁形成的观察可能是对经典模式的一种修改，是真菌针对病毒进行的一种环境保护。与鼻孢子虫病通常的组织病理学表现不同，病毒感染病例缺乏特征性的明显炎症反应。这一发现，连同该病变频繁复发的相对较短间隔，使我们推测存在局部获得性免疫缺陷状态。这种局部免疫缺陷可能是由免疫抑制机制引起的。这可能是由乳头瘤病毒介导的，和/或由于宿主病毒感染细胞的弱抗原性，这些细胞仅含有未整合形式的病毒DNA拷贝。
