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体外受精中使用促性腺激素释放激素拮抗剂方案的周期安排:批量体外受精是否可行?

Scheduling cycles with gonadotropin-releasing hormone antagonist protocol in in vitro fertilization: Is there a scope in batch in vitro fertilization?

作者信息

Gutgutia Rohit, Rao Sameer, Garcia-Velasco Juan, Basu Susmita

机构信息

Department of Reproductive Medicine, NOVA IVI Fertility, Kolkata, West Bengal, India.

Medical Affairs (Women's Healthcare), MSD Pharmaceuticals Private Limited, Mumbai, Maharashtra, India.

出版信息

J Hum Reprod Sci. 2014 Oct-Dec;7(4):230-5. doi: 10.4103/0974-1208.147489.

Abstract

In India, a practice of "Batch in vitro fertilization (IVF)" has evolved in many infertility centers in an effort to align infertility management with logistics. A "Batch IVF" is an approach where the menstrual cycles of multiple women are programmed, such that they can undergo all the processes; from stimulation until embryo transfer about the same time. In "Batch IVF", the day for initiating stimulation is calculated retrospectively from the day the visiting embryologist is available at the clinic (day of ovum pick-up). Aligning the cycles of multiple women with steroids followed by down regulation with long gonadotropin-releasing hormone agonist (GnRH-A) is one of the currently employed methods for batching. There is sufficient evidence on scheduling cycles with steroids in GnRH-An protocol without compromising on the outcome. The objective of this paper is to provide evidence-based clinical concept on scheduling cycles in "Batch IVF" setup with GnRH-An protocol through literature review.

摘要

在印度,许多不孕不育中心发展出了一种“批量体外受精(IVF)”的做法,旨在使不孕不育治疗与后勤安排相协调。“批量IVF”是一种对多名女性的月经周期进行规划的方法,以便她们能够在大致相同的时间经历从刺激到胚胎移植的所有过程。在“批量IVF”中,开始刺激的日期是从临床胚胎学家在诊所可用的那天(取卵日)进行追溯计算的。使多名女性的周期与类固醇同步,随后使用长效促性腺激素释放激素激动剂(GnRH-A)进行降调节,是目前用于批量处理的方法之一。有充分的证据表明,在GnRH-An方案中使用类固醇安排周期不会影响治疗结果。本文的目的是通过文献综述,为在“批量IVF”设置中使用GnRH-An方案安排周期提供基于证据的临床概念。

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