毛喉素对鸡胚心血管发育的致畸作用。
The teratogenic effect of forskolin on cardiovascular development in the chick embryo.
作者信息
Nishikawa T, Sato A, Kanai T, Kasajima T, Nakajima Y, Ando M, Takao A
机构信息
Department of Pathology, Tokyo Women's Medical College, Japan.
出版信息
Reprod Toxicol. 1989;3(2):139-42. doi: 10.1016/0890-6238(89)90048-8.
The cardiovascular teratogenicity and embryotoxicity of forskolin, a potent activator of adenylate cyclase, was studied in the chick embryo. The drug was topically applied to the surface of the chorioallantoic membrane in the vicinity of the embryonic heart on the 4th day of incubation (Hamburger-Hamilton developmental stage 24). Cardiovascular malformations were induced in 51% of embryos treated with forskolin doses larger than 1 x 10(-8) mol/egg. Major malformations included remnant of the left 4th aortic arch and ventricular septal defect. These results indicate that forskolin induces cardiovascular malformations in the chick embryo and suggest that increased levels of cyclic 3',5'-adenosine monophosphate produced by forskolin may be related to the malformations observed.
研究了腺苷酸环化酶的强效激活剂福斯高林在鸡胚中的心血管致畸性和胚胎毒性。在孵化第4天（汉伯格-汉密尔顿发育阶段24），将该药物局部应用于胚胎心脏附近的绒毛尿囊膜表面。用大于1×10⁻⁸摩尔/蛋的福斯高林剂量处理的胚胎中，51%出现了心血管畸形。主要畸形包括左第四主动脉弓残留和室间隔缺损。这些结果表明，福斯高林可诱导鸡胚出现心血管畸形，并提示福斯高林产生的3',5'-环磷酸腺苷水平升高可能与观察到的畸形有关。
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