普萘洛尔与节拍化疗联合靶向治疗：复发性转移性血管肉瘤的持续完全缓解
Targeted therapy with propranolol and metronomic chemotherapy combination: sustained complete response of a relapsing metastatic angiosarcoma.
作者信息
Banavali Shripad, Pasquier Eddy, Andre Nicolas
机构信息
Department of Medical and Pediatric Oncology, Tata Memorial Centre, Mumbai 400 012, India ; Metronomics Global Health Initiative, Marseille, France.
Metronomics Global Health Initiative, Marseille, France ; Aix Marseille Université, Inserm, CRO2 UMR_S 91, Marseille 13005, France.
出版信息
Ecancermedicalscience. 2015 Jan 8;9:499. doi: 10.3332/ecancer.2015.499. eCollection 2015.
We report here a case of a 69-year-old woman with a relapsing metastatic angiosarcoma treated with a combination of metronomic chemotherapy and propranolol. The beta blockers were added since the tumour was positive for betaadrenergic receptor. A complete response was quickly obtained and lasted for 20 months. With this case, the combination of metronomic chemotherapy and propranolol in angiosarcoma warrants additional studies and illustrates the potential of metronomics to generate innovative yet inexpensive targeted therapies for both high-income and low-/middle-income countries.
我们在此报告一例69岁复发性转移性血管肉瘤女性患者，接受了节拍化疗与普萘洛尔联合治疗。由于肿瘤β-肾上腺素能受体呈阳性，故加用了β受体阻滞剂。很快获得了完全缓解，且持续了20个月。通过该病例，节拍化疗与普萘洛尔联合治疗血管肉瘤值得进一步研究，并说明了节拍化疗有潜力为高收入国家以及低收入/中等收入国家开发创新且廉价的靶向治疗方法。
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