Chen Chun-Yong, Zhong Jian-Hong, Liu Jing-Li
Department of Neurology, The First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Department of Hepatobiliary Surgery, The Affiliated Tumor Hospital, Guangxi Medical University, Nanning, Guangxi 530021, P.R. China.
Oncol Lett. 2015 Feb;9(2):721-726. doi: 10.3892/ol.2014.2733. Epub 2014 Nov 24.
Hepatocellular carcinoma (HCC) is the most common malignant cancer of the liver and the third ranking cause of cancer-related mortality worldwide. Following the diagnosis of HCC, intrahepatic and extrahepatic metastasis patients account for ~50-75% of all HCC cases, lung and regional lymph nodes metastasis are the most common; metastasis to bone, skin and adrenal glands are rare, orbit metastasis and intracranial invasion are extremely rare. The present study reports the rare case of a patient with HCC that metastasized to the head. The patient presented with retrobulbar and intracranial invasion, and sub-scalp extension. Based on imaging findings, the lesion was initially misdiagnosed as meningioma, however, postoperative pathological examinations resulted in a definitive diagnosis of HCC metastasis. Based on the present case and a review of the relevant literature published since 2009, the current study recommends that metastasis must be considered when diagnosing retrobulbar head lesions in patients with HCC, regardless of contradictory imaging findings and other clinical indicators, which may closely mimic the original head lesion.
肝细胞癌（HCC）是最常见的肝脏恶性肿瘤，也是全球癌症相关死亡的第三大原因。在HCC诊断后，肝内和肝外转移患者约占所有HCC病例的50-75%，肺和区域淋巴结转移最为常见；骨、皮肤和肾上腺转移罕见，眼眶转移和颅内侵犯极为罕见。本研究报告了1例HCC转移至头部的罕见病例。该患者出现球后和颅内侵犯以及头皮下扩展。基于影像学表现，该病变最初被误诊为脑膜瘤，然而，术后病理检查确诊为HCC转移。基于本病例及对2009年以来发表的相关文献的回顾，本研究建议，在诊断HCC患者的球后头部病变时，无论影像学表现和其他临床指标是否矛盾，均须考虑转移的可能，因为这些表现可能与原发头部病变极为相似。
