Naha Sowjanya, Naha Kushal, Pandit Vinay R, Balasubramanian R
Department of Medicine, Kasturba Hospital, Manipal, Karnataka, India.
Department of Medicine, Indira Gandhi Medical College and Research Institute, Puducherry, India.
Avicenna J Med. 2015 Jan-Mar;5(1):6-10. doi: 10.4103/2231-0770.148501.
Microalbuminuria is a known indicator of atherosclerosis and its association with ischemic heart disease (IHD) has been extensively studied in the diabetic population. The significance of urine microalbumin in non-diabetics, however, is yet to be elucidated.
To determine whether an independent association exists between microalbuminuria and IHD in non-diabetic Asian-Indians, and the level of microalbuminuria predictive of concomitant IHD.
A cross-sectional case-control study was conducted between July 2009 and June 2011. Non-diabetic patients undergoing evaluation for IHD were divided into cases and controls, based on the presence or absence of IHD, respectively. Fifty cases and 50 controls were included, and matched by age, sex, smoking habit, hypertension and body-mass index (BMI). Fasting blood glucose (FBG), fasting lipid profile, and urine microalbumin were recorded for all patients.
Mean fasting glucose, mean low density lipoprotein (LDL)-cholesterol and mean urine microalbumin were all significantly higher in cases compared to controls. Urine microalbumin was independently associated with IHD, and microalbumin greater than 12.6 mg/g was predictive of IHD (OR: 13.5; 95% CI, 4.6-39.9; P < 0.001).
Urine microalbumin is independently associated with IHD in non-diabetics and levels greater than 12.6 mg/g are predictive of IHD.
微量白蛋白尿是动脉粥样硬化的已知指标，其与缺血性心脏病（IHD）的关联已在糖尿病患者群体中得到广泛研究。然而，非糖尿病患者尿微量白蛋白的意义尚待阐明。
确定非糖尿病亚洲印度人中微量白蛋白尿与IHD之间是否存在独立关联，以及预测并发IHD的微量白蛋白尿水平。
于2009年7月至2011年6月进行了一项横断面病例对照研究。因IHD接受评估的非糖尿病患者根据是否患有IHD分别分为病例组和对照组。纳入50例病例和50例对照，并按年龄、性别、吸烟习惯、高血压和体重指数（BMI）进行匹配。记录所有患者的空腹血糖（FBG）、空腹血脂谱和尿微量白蛋白。
与对照组相比，病例组的平均空腹血糖、平均低密度脂蛋白（LDL）胆固醇和平均尿微量白蛋白均显著更高。尿微量白蛋白与IHD独立相关，大于12.6 mg/g的微量白蛋白可预测IHD（OR：13.5；95%CI，4.6 - 39.9；P < 0.001）。
非糖尿病患者中尿微量白蛋白与IHD独立相关，大于12.6 mg/g的水平可预测IHD。
