Jain Ankit, Kumar Vikas, Shrimal Kunal
Department of Internal Medicine, Saraswathi Institute of Medical Sciences, Anwarpur, Uttar Pradesh, India.
Heart Views. 2025 Jan-Mar;26(1):28-33. doi: 10.4103/heartviews.heartviews_114_23. Epub 2025 Jul 16.
Microalbuminuria has been established as a marker for increased cardiovascular risk in diabetic patients. Nonetheless, its correlation with ischemic heart disease (IHD) among individuals without diabetes has received limited attention. The current study was performed to explore the potential link between microalbuminuria and IHD in nondiabetic subjects.
During 2 years, a case-control study was executed, encompassing 100 individuals without diabetes who had IHD as cases, and an equal number of 100 non-IHD controls. Microalbuminuria levels were evaluated alongside diverse cardiovascular risk factors in both sets. IBM-SPSS version 25.0 was used for statistical analysis.
The mean age, gender distribution, and body mass index were similar between the cases and controls. There was a higher prevalence of smokers and alcohol users among the cases compared to controls. In addition, a positive family history of IHD was more prevalent in the case group. In the case group, the mean values of systolic blood pressure, diastolic blood pressure, mean arterial pressure, fasting blood glucose, cholesterol, low-density lipoprotein (LDL), serum creatinine, and urine albumin levels were notably elevated compared to the control group. A significant increase in microalbuminuria levels in the case group was observed.
The results reveal a substantial link between microalbuminuria and IHD in individuals without diabetes. Microalbuminuria was independently correlated with major cardiovascular risk factors, including alcohol and cigarette use, and higher levels of cholesterol, LDL, and serum creatinine. These findings suggest that urine albumin measurements could serve as an early marker for identifying cardiovascular disease risk factors and potentially aid in preventive interventions in the general population.
微量白蛋白尿已被确立为糖尿病患者心血管风险增加的标志物。然而，其在非糖尿病个体中与缺血性心脏病（IHD）的相关性受到的关注有限。本研究旨在探讨非糖尿病受试者中微量白蛋白尿与IHD之间的潜在联系。
在两年期间，进行了一项病例对照研究，纳入100例无糖尿病的IHD患者作为病例组，以及数量相等的100例非IHD对照。对两组患者的微量白蛋白尿水平以及各种心血管危险因素进行了评估。使用IBM-SPSS 25.0版进行统计分析。
病例组和对照组的平均年龄、性别分布和体重指数相似。与对照组相比，病例组中吸烟者和饮酒者的比例更高。此外，IHD的阳性家族史在病例组中更为普遍。病例组的收缩压、舒张压、平均动脉压、空腹血糖、胆固醇、低密度脂蛋白（LDL）、血清肌酐和尿白蛋白水平的平均值明显高于对照组。病例组的微量白蛋白尿水平显著升高。
结果显示非糖尿病个体中微量白蛋白尿与IHD之间存在密切联系。微量白蛋白尿与主要心血管危险因素独立相关，包括饮酒和吸烟，以及较高水平的胆固醇、LDL和血清肌酐。这些发现表明，尿白蛋白检测可作为识别心血管疾病危险因素的早期标志物，并可能有助于在普通人群中进行预防性干预。
