Sorbonne Universités, UPMC UNIV Paris 06, Institut Parisien de Chimie Moléculaire, UMR CNRS 8232, Case 229 , 4 Place Jussieu, 75252 Paris Cedex 05, France.
J Am Chem Soc. 2015 Feb 25;137(7):2448-51. doi: 10.1021/ja512728f. Epub 2015 Feb 10.
A facile C-H activation and functionalization of aromatic imines is presented using low-valent cobalt catalysts. Using Co(PMe3)4 as catalyst we have developed an efficient and simple protocol for the C-H/hydroarylation of alkynes with an anti selectivity. Deuterium-labeling experiments, DFT calculations coupled with the use of a well-defined catalyst have for the first time shed light on the elusive black box of cobalt catalyzed C-H functionalization.
本文使用低价钴催化剂实现了芳基亚胺的 C-H 活化和官能团化。我们使用 Co(PMe3)4 作为催化剂，开发了一种高效、简单的炔烃与反式选择性 C-H/芳基化反应的方法。氘标记实验、与使用定义明确的催化剂相结合的密度泛函理论计算首次揭示了钴催化 C-H 官能团化这一难以捉摸的“黑匣子”。
