Technische Universität Braunschweig, Institut für Organische Chemie , Hagenring 30, 38106 Braunschweig, Germany.
Org Lett. 2015 Feb 6;17(3):596-9. doi: 10.1021/ol503609d. Epub 2015 Jan 27.
A palladium-catalyzed three-component coupling involving in situ generated arynes, terminal alkynes, and vinyl cyclopropane dicarboxylate has been developed. The process demonstrates the first example of aryne chemistry combined with the ring opening of vinyl cyclopropanes. This efficient method using readily available starting materials generates two new carbon-carbon bonds in one pot.
钯催化的三组分偶联反应涉及原位生成的芳炔、末端炔烃和乙烯基环丙烷二羧酸酯。该过程展示了芳炔化学与乙烯基环丙烷开环相结合的首例实例。这种使用易得起始原料的有效方法可在一锅反应中生成两个新的碳-碳键。
