State key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zuchongzhi Road, Shanghai 201203, People's Republic of China.
Org Biomol Chem. 2010 Jun 28;8(13):3073-7. doi: 10.1039/c004233a. Epub 2010 May 18.
A novel and rapid assembly of an interesting class of furocoumarins-4H-furo[3,2-c]chromen-4-ones has been successfully achieved using one-pot sequential coupling/cyclization strategy with easily available starting materials 3-bromo-4-acetoxycoumarins and terminal alkynes. The key synthesis involves Pd/Cu-catalyzed alkynylation with in situ prepared dialkynylzincs followed by intramolecular hydroalkoxylation.
一种新颖而快速的方法成功地将一类有趣的呋喃并香豆素-4H-呋喃并[3,2-c]色烯-4-酮进行了一锅法顺序偶联/环化反应，使用了易于获得的起始原料 3-溴-4-乙酰氧基香豆素和末端炔烃。关键的合成涉及 Pd/Cu 催化的炔基化反应，随后是原位制备的二炔基锌与分子内氢烷氧基化反应。
