Linn Rebecca L, Minturn Lucy, Yee Lynn M, Maniar Kruti, Zhang Yanming, Fritsch Michael K, Kashireddy Papreddy, Kapur Raj, Ernst Linda M
1 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
Pediatr Dev Pathol. 2015 Mar-Apr;18(2):146-54. doi: 10.2350/14-12-1583-CR.1. Epub 2015 Jan 27.
We report a dichorionic twin gestation with diffuse placental mesenchymal dysplasia (PMD) and androgenetic biparental mosaicism (ABM) involving one twin's placenta with complete absence of fetal development for that twin. To our knowledge, this is the 1st reported case of PMD without fetal development. We discuss the gross, histologic, and genetic hallmarks of PMD and the spectrum of variability depending on degree and distribution of ABM.
我们报告了一例双绒毛膜双胎妊娠，其中一胎胎盘存在弥漫性胎盘间充质发育异常（PMD）和双单亲嵌合体（ABM），该胎儿完全没有发育。据我们所知，这是首例报道的无胎儿发育的PMD病例。我们讨论了PMD的大体、组织学和遗传学特征，以及取决于ABM程度和分布的变异范围。
