Michalany J, Michalany N S
Departament of Pathological Anatomy Escola Paulista de Medicina, São Paulo, Brazil.
Hansenol Int. 1989 Dec;14(2):83-6.
Based on a new morphological concept and classification of granulomatous inflammation: the polar granulomas, on the histogenesis of the tuberculoid granuloma of the positive Mitsuda test and on the relationship between the degree of histogenetic differentiation and behaviour of tumors, the Authors concluded that the "benign" or "malignant" behaviour of hanseniasis depends on the degree of tuberculoid differentiation of the lesions. If the lesion is histologically well differentiated toward a polar tuberculoid granuloma (tuberculoid hanseniasis) it will have a "benign" behaviour. On the contrary, if this differentiation is absent (virchowian hanseniasis) or poor (interpolar borderline hanseniasis) the behaviour of the lesion will be "malignant".
极性肉芽肿，关于阳性密特苏达试验结核样肉芽肿的组织发生，以及关于肿瘤组织发生分化程度与行为之间的关系，作者们得出结论，麻风的“良性”或“恶性”行为取决于病变的结核样分化程度。如果病变在组织学上向极性结核样肉芽肿充分分化（结核样麻风），它将具有“良性”行为。相反，如果这种分化不存在（维丘沃氏麻风）或很差（极间边界性麻风），病变的行为将是“恶性”的。
