异常血液流变学与慢性低度炎症：Lewis阴性受试者动脉粥样硬化加速和冠状动脉疾病的潜在危险因素。
Abnormal blood rheology and chronic low grade inflammation: possible risk factors for accelerated atherosclerosis and coronary artery disease in Lewis negative subjects.
作者信息
Alexy Tamas, Pais Eszter, Wenby Rosalinda B, Mack Wendy J, Hodis Howard N, Kono Naoko, Wang Jun, Baskurt Oguz K, Fisher Timothy C, Meiselman Herbert J
机构信息
University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA; Emory University, School of Medicine, Atlanta, GA 30322, USA.
University of Southern California, Keck School of Medicine, Los Angeles, CA 90033, USA.
出版信息
Atherosclerosis. 2015 Mar;239(1):248-51. doi: 10.1016/j.atherosclerosis.2015.01.015. Epub 2015 Jan 21.
OBJECTIVE
To test the hypothesis that abnormal hemorheology and chronic low-grade inflammation are more prevalent in Lewis negative individuals, possibly contributing to premature atherosclerosis.
METHODS AND RESULTS
We enrolled 223 healthy subjects (154 females, mean age: 64yrs). Conventional risk factors, markers of inflammation and hemorheological profiles were measured; Lewis blood group was determined by serology. Conventional risk factors (age, gender, BMI, blood pressure, lipid profile, smoking habit) did not differ among Lewis phenotypes. However, markers of inflammation (WBC, hs-CRP, ESR) were significantly elevated and rheological parameters (RBC aggregation, plasma viscosity) were abnormal in Lewis negative subjects, especially when compared to the Le(a-b+) group.
CONCLUSIONS
With a prevalence of 33% in select populations, our data support the hypothesis that Le(a-b-) represents a pro-inflammatory phenotype that may contribute to the elevated cardiovascular risk in this group.
目的
检验以下假设，即血液流变学异常和慢性低度炎症在Lewis阴性个体中更为普遍，这可能导致动脉粥样硬化过早发生。
方法与结果
我们纳入了223名健康受试者（154名女性，平均年龄：64岁）。测量了传统危险因素、炎症标志物和血液流变学指标；通过血清学确定Lewis血型。传统危险因素（年龄、性别、体重指数、血压、血脂谱、吸烟习惯）在Lewis血型表型之间没有差异。然而，Lewis阴性受试者的炎症标志物（白细胞、高敏C反应蛋白、红细胞沉降率）显著升高，流变学参数（红细胞聚集、血浆粘度）异常，尤其是与Le(a-b+)组相比时。
结论
在特定人群中，Le(a-b-)的患病率为33%，我们的数据支持以下假设，即Le(a-b-)代表一种促炎表型，可能导致该组心血管风险升高。
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