Tang T-Y Dora, Brooks Nicholas J, Ces Oscar, Seddon John M, Templer Richard H
School of Chemistry, University of Bristol, Cantock's Close, Bristol BS8 1TS, UK.
Soft Matter. 2015 Mar 14;11(10):1991-7. doi: 10.1039/c4sm02724h.
Non-equilibrium pathways of lyotropic phase transitions such as the lamellar to inverse bicontinuous cubic phase transition are important dynamical processes resembling cellular fusion and fission processes which can be exploited in biotechnological processes such as drug delivery. However, utilising and optimising these structural transformations for applications require a detailed understanding of the energetic pathways which drive the phase transition. We have used the high pressure X-ray diffraction technique to probe the lamellar to Q(G)(II) phase transition in limited hydration monolinolein on the millisecond time scale. Our results show that the phase transition goes via a structural intermediate and once the Q(G)(II) phase initially forms the elastic energy in the bilayer drives this structure to its equilibrium lattice parameter.
溶致液晶相转变的非平衡途径，如层状相向反相双连续立方相的转变，是重要的动力学过程，类似于细胞融合和裂变过程，可用于药物递送等生物技术过程。然而，要将这些结构转变用于实际应用并进行优化，需要详细了解驱动相变的能量途径。我们利用高压X射线衍射技术，在毫秒时间尺度上研究了有限水合单油酸甘油酯中层状相向Q(G)(II)相的转变。我们的结果表明，相变通过一个结构中间体进行，并且一旦Q(G)(II)相最初形成，双层中的弹性能就会驱动该结构达到其平衡晶格参数。
