Khawar Babar, Abbasi Muddasir Hassan, Sheikh Nadeem
Cell and Molecular Biology Lab, Department of Zoology, University of the Punjab, Quaid-e-Azam Campus, Lahore, Pakistan.
Department of Zoology, Governments. College of Science, Wahdat Road, Lahore, Pakistan.
Eur J Med Res. 2015 Jan 28;20(1):7. doi: 10.1186/s40001-015-0083-y.
Cytokines have always been of great interest due to their vast potential and participation in the progression and pathogenesis of various ailments. Interleukin-32 (IL-32) is a recently identified cytokine, whose gene is located on human chromosome 16 p13.3, with eight exons and six splice variants (IL-32α to IL-32ζ). IL-32α, the most abundant form, is secreted by different types of cells including T cells, natural killer (NK) cells, monocytes, endothelial cells and epithelial cells. It acts as a preferential mediator and effector of abnormal immune responses to multiple inflammatory and auto immune diseases including rheumatoid arthritis, chronic obstructive pulmonary disease (COPD), inflammatory bowel disease (IBD), etc. It was found to stimulate the induction of various chemokines, pro-inflammatory cytokines including IL-1β, IL-6, IL-8, TNF-α and macrophage inflammatory protein-2 (MIP-2). Hence, IL-32 mediates the crucial interplay among immune system and body cells during pathogenesis of various insults. The aim of the present effort is to summarize the role, mechanism of pathogenesis and potential therapeutic applications of IL-32 in different systemic infections and diseased conditions.
细胞因子因其巨大的潜力以及参与各种疾病的进展和发病机制而一直备受关注。白细胞介素-32（IL-32）是一种最近发现的细胞因子，其基因位于人类染色体16 p13.3上，有八个外显子和六个剪接变体（IL-32α至IL-32ζ）。IL-32α是最丰富的形式，由包括T细胞、自然杀伤（NK）细胞、单核细胞、内皮细胞和上皮细胞在内的不同类型细胞分泌。它是对多种炎症和自身免疫性疾病（包括类风湿性关节炎、慢性阻塞性肺疾病（COPD）、炎症性肠病（IBD）等）异常免疫反应的优先介质和效应器。研究发现它能刺激多种趋化因子、促炎细胞因子（包括IL-1β、IL-6、IL-8、TNF-α和巨噬细胞炎性蛋白-2（MIP-2））的诱导。因此，IL-32在各种损伤的发病机制中介导免疫系统与身体细胞之间的关键相互作用。本研究的目的是总结IL-32在不同全身感染和疾病状态下的作用、发病机制及潜在治疗应用。
