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人类和动物正链RNA病毒复制过程中RNA结构的多样作用及相互作用

Diverse roles and interactions of RNA structures during the replication of positive-stranded RNA viruses of humans and animals.

作者信息

Tuplin Andrew

机构信息

School of Molecular and Cellular Biology, Faculty of Biological Sciences, University of Leeds, Leeds, LS2 9JT, UK.

出版信息

J Gen Virol. 2015 Jul;96(Pt 7):1497-503. doi: 10.1099/vir.0.000066. Epub 2015 Jan 27.

DOI:10.1099/vir.0.000066
PMID:25626680
Abstract

Positive-stranded RNA viruses include important human, animal and plant pathogens. Their genomes are able to fold into complex structures stabilized by base pairing between individual nucleotides, many of which are highly conserved and have essential functions during virus replication. With new studies and technological advances the diversity of roles, mechanisms and interactions in which such structured viral RNA functions is becoming increasingly clear. It is also evident that many RNA structures do not function as discrete elements but through mechanisms involving multiple, long-range and often dynamic RNARNA interactions. Through a range of examples and recent advances, this review illustrates the diverse roles and mechanisms of structured viral RNA during the replication of positive-stranded RNA viruses infecting humans and animals.

摘要

正链RNA病毒包括重要的人类、动物和植物病原体。它们的基因组能够折叠成由单个核苷酸之间的碱基配对稳定的复杂结构，其中许多结构高度保守，并且在病毒复制过程中具有重要功能。随着新的研究和技术进步，这种结构化病毒RNA发挥作用的角色、机制和相互作用的多样性越来越清晰。同样明显的是，许多RNA结构并非作为离散元件发挥作用，而是通过涉及多个、长距离且通常是动态的RNA-RNA相互作用的机制发挥作用。通过一系列实例和最新进展，本综述阐述了结构化病毒RNA在感染人类和动物的正链RNA病毒复制过程中的多种作用和机制。

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