Brierley Ian, Pennell Simon, Gilbert Robert J C
Division of Virology, Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QP, UK. ib
Nat Rev Microbiol. 2007 Aug;5(8):598-610. doi: 10.1038/nrmicro1704.
RNA pseudoknots are structural elements found in almost all classes of RNA. First recognized in the genomes of plant viruses, they are now established as a widespread motif with diverse functions in various biological processes. This Review focuses on viral pseudoknots and their role in virus gene expression and genome replication. Although emphasis is placed on those well defined pseudoknots that are involved in unusual mechanisms of viral translational initiation and elongation, the broader roles of pseudoknots are also discussed, including comparisons with relevant cellular counterparts. The relationship between RNA pseudoknot structure and function is also addressed.
RNA假结是几乎在所有类型的RNA中都能找到的结构元件。它最初在植物病毒基因组中被识别出来，如今已被确认为一种广泛存在的基序，在各种生物过程中具有多种功能。本综述聚焦于病毒假结及其在病毒基因表达和基因组复制中的作用。虽然重点是那些参与病毒翻译起始和延伸异常机制的明确定义的假结，但也讨论了假结更广泛的作用，包括与相关细胞对应物的比较。还探讨了RNA假结结构与功能之间的关系。
