Moore David J, Barlow Matthew A, Gonzales Joaquin U, McGowan Cheri L, Pawelczyk James A, Proctor David N
Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania Intercollege Graduate Degree Program in Physiology, The Pennsylvania State University, University Park, Pennsylvania.
Noll Laboratory, Department of Kinesiology, The Pennsylvania State University, University Park, Pennsylvania Department of Biology, Eastern New Mexico University, Portales, New Mexico.
Physiol Rep. 2015 Jan 27;3(1). doi: 10.14814/phy2.12275. Print 2015 Jan 1.
While muscle sympathetic nerve activity (MSNA) is elevated with advancing age, correlational evidence suggests that, in contrast to men, basal MSNA is not related to resting lower limb hemodynamics in women. However, limited data exists in women that have attempted to directly assess the degree of limb sympathetic vasoconstrictor tone, and whether it is altered with age. To address this issue, we measured changes in femoral artery vascular conductance (FVC) during an acute sympatho-inhibitory stimulus (-60 mm Hg neck suction, NS) in groups of healthy younger (n = 8, 23 ± 1 years) and older (n = 7, 66 ± 1 years) women. The percent change in FVC in response to NS was significantly augmented in the older (P = 0.006 vs. young) women. Although NS caused no significant change (3 ± 3%, P = 0.33) in FVC in the young women, there was a robust increase in FVC (21 ± 5%, P = 0.003) in the old women. Collectively, these findings provide evidence that in women, leg sympathetic vasoconstrictor tone emerges with age.
虽然随着年龄增长肌肉交感神经活动（MSNA）会升高，但相关证据表明，与男性不同，女性的基础MSNA与静息下肢血流动力学无关。然而，在试图直接评估肢体交感缩血管张力程度及其是否随年龄变化的女性中，现有数据有限。为解决这一问题，我们在一组健康年轻女性（n = 8，23±1岁）和老年女性（n = 7，66±1岁）中测量了急性交感神经抑制刺激（-60 mmHg颈部负压吸引，NS）期间股动脉血管传导性（FVC）的变化。老年女性对NS反应时FVC的百分比变化显著增加（与年轻女性相比，P = 0.006）。虽然NS在年轻女性中未引起FVC的显著变化（3±3%，P = 0.33），但老年女性的FVC有显著增加（21±5%，P = 0.003）。总体而言，这些发现提供了证据，表明在女性中，腿部交感缩血管张力会随着年龄出现。
