Catenacci G, Tringali S, Florio I, Pezzagno G
Dipartimento Medicina Preventiva, Occupazionale e di Comunità, Università di Pavia.
G Ital Med Lav. 1989 Sep;11(5):215-8.
Results of a longitudinal study on the yearly decline of two pulmonary parameters are reported. All subjects were workers in a refractory material factory and exposed to dust with low silica content. The study brought about an annual measurement of two spirometric parameters (VC and FEV1) during a 13 year period of follow up on 113 subjects. 56% and 57.5% of them showed annual decreases of VC and FEV1 statistically significant. The trend of the two functional parameters over time was studied both in the whole group of workers and in subgroups obtained from occupational exposure levels, smoking habit, age. The most affected volumetric index was the VC. The 3 risk indicators considered (occupational exposure, smoking habit and age) all negatively influence the VC decrease; however, the effect is statistically significant only for smoking habit. The FEV1 changes with reference to the above mentioned risk indicators are less clear. From the whole group a number of 15 losers were selected.
报告了一项关于两项肺功能参数逐年下降情况的纵向研究结果。所有受试者均为耐火材料厂工人，接触低硅含量粉尘。该研究在113名受试者的13年随访期间，每年测量两项肺量计参数（肺活量和第一秒用力呼气容积）。其中56%和57.5%的受试者肺活量和第一秒用力呼气容积出现了具有统计学意义的年度下降。在全体工人以及根据职业接触水平、吸烟习惯、年龄划分的亚组中，研究了这两项功能参数随时间的变化趋势。受影响最大的容积指标是肺活量。所考虑的3个风险指标（职业接触、吸烟习惯和年龄）均对肺活量下降产生负面影响；然而，仅吸烟习惯的影响具有统计学意义。第一秒用力呼气容积相对于上述风险指标的变化不太明显。从整个群体中选出了15名肺活量下降者。
