Innocenti A, Ciapini C, Natale D, Nerozzi F, Pippi P, Selmi M
U.E Medicina del Lavoro - USL 3 (Pistoia) Regione Toscana.
Med Lav. 2006 Jan-Feb;97(1):30-5.
It is well know that wood dust exposure can induce sino-nasal cancers, rhinitis and asthma; induction of chronic bronchial obstruction, pulmonary fibrosis and lung cancer are also suggested, but data are often inconclusive and in disagreement.
The study evaluated the decrease in lung function in a group of 31 non-smokers exposed to high levels of wood dust (> 5 mg/m3 also) and in 2 non-smokering control groups with comparable lung function tests at first examination: 39 mechanical workers without respiratory hazards (group 1) and 30 forestry workers (group 2).
Assessment of lung function was repeated at least 5 times during 11.2 +/- 2.4 years for wood workers and 12.3 +/- 4.2 years for group 1 (n.s.) and 15.0 +/- 2.6 years for group 2 (p < 0.0005). Linear regression for annual loss of VC and FEV1 was calculated from observed data for each subject.
No significant differences were observed in VC loss or FEV1 loss between woodworkers and control group1 (20.67 +/- 16.9 vs 19.0 +/- 23.2 and 31.37 +/- 22.3 vs 36.2 +/- 22.4 ml/year respectively), while control group 2 showed an accelerated (p < 0.005) VC and FEV1 loss (32.8 +/- 22.1 and 46.6 +/- 21.2 ml/years respectively). In conclusion, the study did not show any alterations in the longitudinal decrease in pulmonary function due to high wood dust exposure levels, perhaps due to the poor inhalability of wood particles that are mostly trapped in the nose; further studies are needed to investigate chronic effects of wood dust exposure on development of Chronic Obstructive Pulmonary Disease, pulmonary fibrosis and also lung cancer.
众所周知，接触木尘可诱发鼻窦癌、鼻炎和哮喘；也有研究提示可诱发慢性支气管阻塞、肺纤维化和肺癌，但相关数据往往缺乏定论且存在争议。
本研究评估了一组31名接触高浓度木尘（>5 mg/m3）的非吸烟者以及另外两组首次检查时肺功能测试结果相当的非吸烟对照组的肺功能下降情况：39名无呼吸危害的机械工人（第1组）和30名林业工人（第2组）。
对木工进行了11.2±2.4年、至少5次的肺功能评估，对第1组进行了12.3±4.2年（无显著差异）的评估，对第2组进行了15.0±2.6年（p<0.0005）的评估。根据每个受试者的观察数据计算肺活量（VC）和第1秒用力呼气容积（FEV1）的年损失率的线性回归。
木工与对照组1之间在VC损失或FEV1损失方面未观察到显著差异（分别为20.67±16.9与19.0±23.2以及31.37±22.3与36.2±22.4 ml/年），而对照组2的VC和FEV1损失加速（p<0.005）（分别为32.8±22.1和46.6±21.2 ml/年）。总之，该研究未显示高木尘暴露水平导致肺功能纵向下降有任何改变，这可能是由于木颗粒大多被困在鼻腔中，吸入性较差；需要进一步研究以调查木尘暴露对慢性阻塞性肺疾病、肺纤维化以及肺癌发展的慢性影响。
