Chandra Vishal, Hong Kyeong-Man
Cancer Cell and Molecular Biology Branch, Research Institute, National Cancer Center, 323 Ilsan-ro, Ilsandong-gu, Goyang, 410-769, Korea.
Arch Pharm Res. 2015 Mar;38(3):321-37. doi: 10.1007/s12272-015-0561-3. Epub 2015 Jan 29.
The concept of epigenetics is now providing the mechanisms by which cells transfer their new environmental-change-induced phenotypes to their daughter cells. However, how extracellular or cytoplasmic environmental cues are connected to the nuclear epigenome remains incompletely understood. Recently emerging evidence suggests that epigenetic changes are correlated with metabolic changes via chromatin remodeling. As many human complex diseases including cancer harbor both epigenetic changes and metabolic dysregulation, understanding the molecular processes linking them has huge implications for disease pathogenesis and therapeutic intervention. In this review, the impacts of metabolic changes on cancer epigenetics are discussed, along with the current knowledge on cancer metabolism and epigenetics.
表观遗传学的概念如今正在揭示细胞将其因环境变化而产生的新表型传递给子代细胞的机制。然而，细胞外或细胞质环境信号如何与核表观基因组相联系，目前仍未完全明确。最近出现的证据表明，表观遗传变化通过染色质重塑与代谢变化相关联。由于包括癌症在内的许多人类复杂疾病都存在表观遗传变化和代谢失调，了解将它们联系起来的分子过程对疾病的发病机制和治疗干预具有重大意义。在这篇综述中，我们将讨论代谢变化对癌症表观遗传学的影响，以及目前关于癌症代谢和表观遗传学的知识。
