Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
Division of Urology, Department of Surgery, University of Alberta, Edmonton, Alberta T6G 2R7, Canada.
Nat Rev Cancer. 2016 Nov;16(11):694-707. doi: 10.1038/nrc.2016.82. Epub 2016 Sep 16.
Alterations in the epigenome and metabolism both affect molecular rewiring in cancer cells and facilitate cancer development and progression. However, recent evidence suggests the existence of important bidirectional regulatory mechanisms between metabolic remodelling and the epigenome (specifically methylation and acetylation of histones) in cancer. Most chromatin-modifying enzymes require substrates or cofactors that are intermediates of cell metabolism. Such metabolites, and often the enzymes that produce them, can transfer into the nucleus, directly linking metabolism to nuclear transcription. We discuss how metabolic remodelling can contribute to tumour epigenetic alterations, thereby affecting cancer cell differentiation, proliferation and/or apoptosis, as well as therapeutic responses.
表观基因组和代谢的改变都会影响癌细胞中的分子重排，并促进癌症的发生和发展。然而，最近的证据表明，代谢重塑与表观基因组（特别是组蛋白的甲基化和乙酰化）之间存在着重要的双向调控机制。大多数染色质修饰酶需要代谢中间产物作为底物或辅助因子。这些代谢物，以及通常产生它们的酶，可以转移到细胞核中，将代谢与核转录直接联系起来。我们讨论了代谢重塑如何促进肿瘤表观遗传改变，从而影响癌细胞的分化、增殖和/或凋亡，以及治疗反应。
