牙龈炎、晚期牙周炎患者与健康受试者唾液表皮生长因子水平的比较。
Comparison of salivary epidermal growth factor levels in patients with gingivitis and advanced periodontitis and healthy subjects.
作者信息
Moosavijazi Mahvash, Rasouli Ghahroudi Amir Alireza, Yaghoobee Siamak, Bayani Mojtaba, Salehi Eisa, Sadrimanesh Roozbeh
机构信息
Assistant Professor, Dental Research Center Dentistry Research Institute Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
Postgraduate Student, Department of Periodontics, School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran.
出版信息
J Dent (Tehran). 2014 Sep;11(5):516-22. Epub 2014 Sep 30.
OBJECTIVE
Epidermal growth factor (EGF) is a polypeptide molecule, with important functions in epithelial growth and wound repair. It exerts its effects on cells by binding to receptors on the cell surface. The aim of this study was to evaluate and compare salivary EGF levels in patients with gingivitis and advanced periodontitis as well as in healthy controls.
MATERIAL AND METHODS
Unstimulated salivary samples were collected from patients with gingivitis and advanced periodontitis and healthy individuals. The clinical parameters of plaque index (PI), bleeding on probing (BOP), probing pocket depth (PPD) and clinical attachment level (CAL) were measured and recorded using a Williams probe. The enzyme-linked immunosorbent assay (ELISA) was used to determine salivary levels of EGF. One-way ANOVA was used for data analysis.
RESULTS
The mean salivary level of EGF in healthy individuals (99.27) was significantly higher than that in patients with gingivitis (61.53). This value in patients with gingivitis (61.53) was also significantly higher than that in subjects with periodontitis (36.14) (P<0.001).
CONCLUSION
The reduction in salivary level of EGF in patients with periodontal disease may be related to the pathogenesis of periodontitis.
目的
表皮生长因子（EGF）是一种多肽分子，在上皮生长和伤口修复中具有重要作用。它通过与细胞表面的受体结合对细胞发挥作用。本研究的目的是评估和比较牙龈炎患者、晚期牙周炎患者以及健康对照者唾液中EGF的水平。
材料与方法
收集牙龈炎患者、晚期牙周炎患者和健康个体的非刺激性唾液样本。使用威廉姆斯探针测量并记录菌斑指数（PI）、探诊出血（BOP）、探诊深度（PPD）和临床附着水平（CAL）等临床参数。采用酶联免疫吸附测定法（ELISA）测定唾液中EGF的水平。采用单因素方差分析进行数据分析。
结果
健康个体唾液中EGF的平均水平（99.27）显著高于牙龈炎患者（61.53）。牙龈炎患者的该值（61.53）也显著高于牙周炎患者（36.14）（P<0.001）。
结论
牙周病患者唾液中EGF水平的降低可能与牙周炎的发病机制有关。
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