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蓝细菌治疗应用的最新进展。

Recent developments in therapeutic applications of Cyanobacteria.

机构信息

a Food Science Lab, Meditbio, Faculty of Sciences and Technology , University of Algarve , Faro , Portugal and.

b AcmeProgen Biotech (India) Pvt. Ltd. , Salem , Tamil Nadu , India.

出版信息

Crit Rev Microbiol. 2016 May;42(3):394-405. doi: 10.3109/1040841X.2014.957640. Epub 2015 Jan 28.

DOI:10.3109/1040841X.2014.957640
PMID:25629310
Abstract

The cyanobacteria (blue-green algae) are photosynthetic prokaryotes having applications in human health with numerous biological activities and as a dietary supplement. It is used as a food supplement because of its richness in nutrients and digestibility. Many cyanobacteria (Microcystis sp, Anabaena sp, Nostoc sp, Oscillatoria sp., etc.) produce a great variety of secondary metabolites with potent biological activities. Cyanobacteria produce biologically active and chemically diverse compounds belonging to cyclic peptides, lipopeptides, fatty acid amides, alkaloids and saccharides. More than 50% of the marine cyanobacteria are potentially exploitable for extracting bioactive substances which are effective in killing cancer cells by inducing apoptotic death. Their role as anti-viral, anti-tumor, antimicrobial, anti-HIV and a food additive have also been well established. However, such products are at different stages of clinical trials and only a few compounds have reached to the market.

摘要

蓝藻(蓝绿藻)是光合原核生物,具有多种生物活性,可作为膳食补充剂应用于人类健康。它被用作食品补充剂,因为它富含营养且易消化。许多蓝藻(微囊藻属、鱼腥藻属、念珠藻属、颤藻属等)产生具有强大生物活性的各种次生代谢产物。蓝藻产生具有生物活性和化学多样性的化合物,属于环肽、脂肽、脂肪酸酰胺、生物碱和糖。超过 50%的海洋蓝藻具有可开发性,可从中提取生物活性物质,这些物质通过诱导细胞凋亡而有效杀死癌细胞。它们作为抗病毒、抗肿瘤、抗菌、抗 HIV 和食品添加剂的作用也已得到充分证实。然而,这些产品处于不同的临床试验阶段,只有少数几种化合物已推向市场。

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