Department of Pharmaceutical Chemistry, Bengal College of Pharmaceutical Technology, Dubrajpur 731 123, West Bengal, India.
Department of Pharmacognosy, Bengal School of Technology, Chuchura 712 102, West Bengal, India.
Mar Drugs. 2020 Sep 19;18(9):476. doi: 10.3390/md18090476.
Cancer is at present one of the utmost deadly diseases worldwide. Past efforts in cancer research have focused on natural medicinal products. Over the past decades, a great deal of initiatives was invested towards isolating and identifying new marine metabolites via pharmaceutical companies, and research institutions in general. Secondary marine metabolites are looked at as a favorable source of potentially new pharmaceutically active compounds, having a vast structural diversity and diverse biological activities; therefore, this is an astonishing source of potentially new anticancer therapy. This review contains an extensive critical discussion on the potential of marine microbial compounds and marine microalgae metabolites as anticancer drugs, highlighting their chemical structure and exploring the underlying mechanisms of action. Current limitation, challenges, and future research pathways were also presented.
癌症是目前全球最致命的疾病之一。过去的癌症研究工作主要集中在天然药物产品上。在过去的几十年里,制药公司和研究机构投入了大量的精力来分离和鉴定新的海洋代谢产物。次生海洋代谢产物被视为具有潜在新的药用活性化合物的有利来源,具有广泛的结构多样性和多样的生物活性;因此,这是潜在新的抗癌疗法的惊人来源。本综述广泛讨论了海洋微生物化合物和海洋微藻代谢产物作为抗癌药物的潜力,强调了它们的化学结构,并探讨了其作用机制。还提出了当前的局限性、挑战和未来的研究途径。