Kawahara Elisa Ito, Maués Nadine Helena Pelegrino Bastos, dos Santos Klinsmann Carolo, Barbanera Pedro Octávio, Braga Camila Pereira, Fernandes Angélica Henrique
Indian J Biochem Biophys. 2014 Oct;51(5):365-71.
Caloric restriction, defined as a reduction in calorie intake below ad libitum, without malnutrition can have beneficial effects. In this study, we evaluated the impact of caloric restriction of 30 and 60% on calorimetric parameters and oxidative stress in cardiac tissue in rats. Rats were randomly divided into 3 groups (n = 8): G1 = control; G2 = rats exposed to dietary restriction of 30%; and G3 = rats exposed to dietary restriction of 60%. Energy restriction decreased final body weight, oxidation of carbohydrates and lipid, oxygen consumption (VO2), carbon dioxide production (VCO2), resting metabolic rate (RMR), but elevated respiratory quotient (RQ). G3 animals also displayed an imbalance in the oxidant/antioxidant system, as revealed by the decrease in the lipid hydroperoxide (LH) level and GSH-Px activity in heart tissue. In conclusion, dietary restriction decreased oxidative metabolism, as seen by the colorimetric profiles and controlled oxidative stress in cardiac tissue.
热量限制，定义为将卡路里摄入量减少至低于随意摄入量且无营养不良，可产生有益效果。在本研究中，我们评估了30%和60%的热量限制对大鼠心脏组织热量参数和氧化应激的影响。大鼠被随机分为3组（n = 8）：G1 = 对照组；G2 = 接受30%饮食限制的大鼠；G3 = 接受60%饮食限制的大鼠。能量限制降低了最终体重、碳水化合物和脂质的氧化、耗氧量（VO2）、二氧化碳产生量（VCO2）、静息代谢率（RMR），但提高了呼吸商（RQ）。G3组动物还表现出氧化/抗氧化系统失衡，心脏组织中脂质过氧化氢（LH）水平和谷胱甘肽过氧化物酶（GSH-Px）活性降低即表明了这一点。总之，从比色分析结果和心脏组织中受控的氧化应激可以看出，饮食限制降低了氧化代谢。
