N-乙酰半胱氨酸对链脲佐菌素诱导的糖尿病大鼠血脂异常和碳水化合物代谢的影响。
Effect of N-Acetylcysteine on Dyslipidemia and Carbohydrate Metabolism in STZ-Induced Diabetic Rats.
作者信息
Kaga Anderson Kiyoshi, Barbanera Pedro Octavio, do Carmo Nágilla Orleanne Lima, Rosa Lucas Rodolfo de Oliveira, Fernandes Ana Angélica Henrique
机构信息
Department of Chemistry and Biochemistry, Institute of Biosciences of Botucatu, Sao Paulo State University (UNESP), Rua Professor Doutor Antônio Celso Wagner Zanin s/n, Distrito de Rubião Júnior, 18618-689 Botucatu, SP, Brazil.
出版信息
Int J Vasc Med. 2018 Jan 28;2018:6428630. doi: 10.1155/2018/6428630. eCollection 2018.
BACKGROUND
Type 1 diabetes mellitus (T1DM) is characterized by insulin-deficient production leading to hyperglycemia, which is associated with diabetic complications such as cardiovascular diseases. Antioxidants have been proving a good alternative to diabetic complications, with N-acetylcysteine (NAC) having antioxidant characteristics. The aim of this study was to assess the effect of NAC on the lipid profile and the atherogenic index (AI) in streptozotocin- (STZ-) induced diabetic rats.
METHOD
32 male Wistar rats (60 days of age) weighting ±250 g were randomly distributed into four groups ( = 8): CTRL: control rats; CTRL+NAC: control rats treated with NAC; DM: diabetic rats; DM+NAC: diabetic rats treated with NAC. T1DM was induced using STZ (60 mg/kg, ip; single dose), and NAC (25 mg/kg/day) was administrated by gavage, for 37 days. The animals received chow and water . After the experimental period, blood and cardiac tissue samples were collected to analyze energetic metabolism, lipid profile, and AI.
RESULTS
NAC decreased ( < 0.01) glycemia, energy intake, carbohydrate, and protein consumption in diabetic rats (DM+NAC), when compared with DM, while the alimentary efficiency was improved ( < 0.01) in treated diabetic rats (DM+NAC). Diabetic rats treated with NAC decreased ( < 0.01) lipid profile and AI in diabetic rats (DM+NAC) when compared to DM.
CONCLUSION
NAC improves lipid profile and decreases AI in STZ-induced diabetic rats.
背景
1型糖尿病（T1DM）的特征是胰岛素分泌不足导致血糖升高，这与心血管疾病等糖尿病并发症相关。抗氧化剂已被证明是治疗糖尿病并发症的良好选择，N-乙酰半胱氨酸（NAC）具有抗氧化特性。本研究的目的是评估NAC对链脲佐菌素（STZ）诱导的糖尿病大鼠血脂谱和动脉粥样硬化指数（AI）的影响。
方法
将32只60日龄、体重±250 g的雄性Wistar大鼠随机分为四组（每组n = 8）：CTRL：对照大鼠；CTRL+NAC：用NAC治疗的对照大鼠；DM：糖尿病大鼠；DM+NAC：用NAC治疗的糖尿病大鼠。使用STZ（60 mg/kg，腹腔注射；单剂量）诱导T1DM，并通过灌胃给予NAC（25 mg/kg/天），持续37天。动物自由进食和饮水。实验期结束后，采集血液和心脏组织样本，分析能量代谢、血脂谱和AI。
结果
与糖尿病大鼠（DM）相比，NAC降低了糖尿病大鼠（DM+NAC）的血糖、能量摄入、碳水化合物和蛋白质消耗（P < 0.01），而治疗后的糖尿病大鼠（DM+NAC）的消化效率得到提高（P < 0.01）。与糖尿病大鼠（DM）相比，用NAC治疗的糖尿病大鼠（DM+NAC）的血脂谱和AI降低（P < 0.01）。
结论
NAC可改善STZ诱导的糖尿病大鼠的血脂谱并降低AI。
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