Hasselmo Karen, Sbarra David A, O'Connor Mary-Frances, Moreno Francisco A
Department of Psychology, University of Arizona, Tucson, Arizona, USA.
Department of Psychiatry, University of Arizona College of Medicine, Tucson, Arizona, USA.
Psychophysiology. 2015 Jun;52(6):736-44. doi: 10.1111/psyp.12409. Epub 2015 Jan 29.
Marital separation is linked to negative mental and physical health; however, the strength of this link may vary across people. This study examined changes in respiratory sinus arrhythmia (RSA), used to assess cardiac vagal control, in recently separated adults (N = 79; M time since separation = 3.5 months). When reflecting on the separation, self-reported psychological distress following the separation interacted with a polymorphism in the serotonin transporter gene (5-HTTLPR) and a relevant single nucleotide polymorphism (SNP), rs25531, to predict RSA. Among people reporting emotional difficulties after the separation, those who were homozygous for the short allele had lower RSA levels while reflecting on their relationship than other genotypes. The findings, although limited by the relatively small sample size, are discussed in terms of how higher-sensitivity genotypes may interact with psychological responses to stress to alter physiology.
婚姻分居与负面的身心健康状况有关；然而，这种关联的强度可能因人而异。本研究调查了近期分居成年人（N = 79；分居后的平均时间 = 3.5个月）的呼吸性窦性心律不齐（RSA）变化，RSA用于评估心脏迷走神经控制。在反思分居情况时，分居后自我报告的心理困扰与血清素转运体基因（5-HTTLPR）的多态性及一个相关单核苷酸多态性（SNP）rs25531相互作用，以预测RSA。在报告分居后情绪困难的人群中，那些携带短等位基因纯合子的人在反思他们的关系时，其RSA水平低于其他基因型。尽管研究结果受样本量相对较小的限制，但还是从高敏感性基因型如何与对应激的心理反应相互作用以改变生理机能的角度进行了讨论。
