Vrshek-Schallhorn Suzanne, Mineka Susan, Zinbarg Richard E, Craske Michelle G, Griffith James W, Sutton Jonathan, Redei Eva E, Wolitzky-Taylor Kate, Hammen Constance, Adam Emma K
Department of Psychology, Northwestern University, Evanston, IL, USA.
Department of Psychology, Northwestern University, Evanston, IL, USA; The Family Institute at Northwestern University, Evanston, IL, USA.
Clin Psychol Sci. 2014 May;2(3):235-248. doi: 10.1177/2167702613499329. Epub 2013 Aug 26.
Meta-analytic evidence supports a gene-environment (G×E) interaction between life stress and the serotonin transporter polymorphism (5-HTTLPR) on depression, but few studies have examined factors that influence detection of this effect, despite years of inconsistent results. We propose that the "candidate environment" (akin to a candidate gene) is key. Theory and evidence implicate major stressful life events (SLEs)-particularly major SLEs-as well as chronic family stress. Participants ( = 400) from the Youth Emotion Project (which began with 627 high school juniors oversampled for high neuroticism) completed up to five annual diagnostic and life stress interviews and provided DNA samples. A significant G×E effect for major SLEs and -carrier genotype was accounted for significantly by major interpersonal SLEs but not significantly by major non-interpersonal SLEs. -carrier genotype and chronic family stress also significantly interacted. Identifying such candidate environments may facilitate future G×E research in depression and psychopathology more broadly.
荟萃分析证据支持生活压力与血清素转运体基因多态性（5-HTTLPR）之间在抑郁症方面存在基因-环境（G×E）相互作用，但尽管多年来结果不一致，却很少有研究探讨影响这种效应检测的因素。我们认为“候选环境”（类似于候选基因）是关键。理论和证据表明重大生活应激事件（SLEs）——尤其是重大SLEs——以及慢性家庭压力与之相关。来自青少年情绪项目的参与者（n = 400）（该项目始于对627名高神经质的高二学生进行过度抽样）完成了多达五次年度诊断和生活压力访谈，并提供了DNA样本。主要人际SLEs对主要SLEs与ε-载体基因型之间显著的G×E效应有显著影响，而主要非人际SLEs则无显著影响。ε-载体基因型与慢性家庭压力之间也存在显著的相互作用。识别此类候选环境可能会更广泛地促进未来抑郁症和精神病理学方面的G×E研究。
