Webb G C, Coggan M, Ichinose A, Board P G
Division of Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra.
Hum Genet. 1989 Jan;81(2):157-60. doi: 10.1007/BF00293893.
In situ hybridization of tritiated cDNA probes for the gene for the B subunit of coagulation factor XIII localized the F13B locus to bands q31-q32.1 on human chromosome 1 and perhaps more precisely to sub-bands 1q31.2 or 1q31.3. Restriction fragment length polymorphisms (RFLPs) were detected with BglII, EcoRI and XbaI. Because the RFLPs detected with each of the three enzymes were concordant in every individual studied and since each showed a similar size difference, it was concluded that the RFLPs probably result from an insertion or deletion of length approximately 0.37-0.4 kb.
用凝血因子 XIII B 亚基基因的氚化 cDNA 探针进行原位杂交，将 F13B 基因座定位到人类染色体 1 的 q31 - q32.1 带，或许更精确地定位到 1q31.2 或 1q31.3 亚带。用 BglII、EcoRI 和 XbaI 检测到了限制性片段长度多态性（RFLP）。由于在每个研究个体中用这三种酶检测到的 RFLP 都是一致的，并且每种酶显示出相似的大小差异，因此得出结论，这些 RFLP 可能是由长度约为 0.37 - 0.4 kb 的插入或缺失导致的。
