小鼠腹腔巨噬细胞与SV40转化的人细胞之间的体细胞杂种。I. 携带SV40基因组的人7号染色体对转化表型的阳性控制。
Somatic cell hybrids between mouse peritoneal macrophages and SV40-transformed human cells. I. Positive control of the transformed phenotype by the human chromosome 7 carrying the SV40 genome.
作者信息
Croce C M, Koprowski H
出版信息
J Exp Med. 1974 Nov 1;140(5):1221-9. doi: 10.1084/jem.140.5.1221.
Abstract
Fusion of mouse peritoneal macrophages with SV40-transformed human cells, deficient in hypoxanthine guanine phosphoribosyltransferase, resulted in the formation of transformed somatic cell hybrids which contained, without exception, the human chromosome 7 carrying the SV40 genome. It is postulated that the hybridization of mouse nondividing cells with human cancer cells could permit the identification of the human "oncogenic" chromosome(s) present in human cancer cells, since such chromosome(s) should be retained by the totality of the mouse-human hybrid cells.
摘要
将缺乏次黄嘌呤鸟嘌呤磷酸核糖转移酶的SV40转化的人细胞与小鼠腹膜巨噬细胞融合，导致形成转化的体细胞杂种，无一例外，这些杂种都含有携带SV40基因组的人类7号染色体。据推测，小鼠非分裂细胞与人癌细胞的杂交可以鉴定出人癌细胞中存在的人类“致癌”染色体，因为这样的染色体应该会被所有的小鼠-人杂交细胞保留下来。
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本文引用的文献
1
THE DIFFERENTIATION OF MONONUCLEAR PHAGOCYTES. MORPHOLOGY, CYTOCHEMISTRY, AND BIOCHEMISTRY.单核吞噬细胞的分化。形态学、细胞化学与生物化学
J Exp Med. 1965 Jan 1;121(1):153-70. doi: 10.1084/jem.121.1.153.
2
SELECTION OF HYBRIDS FROM MATINGS OF FIBROBLASTS IN VITRO AND THEIR PRESUMED RECOMBINANTS.体外成纤维细胞交配产生的杂种及其假定重组体的选择
Science. 1964 Aug 14;145(3633):709-10. doi: 10.1126/science.145.3633.709.
3
Suppression of malignancy by cell fusion.通过细胞融合抑制恶性肿瘤
Nature. 1969 Jul 26;223(5204):363-8. doi: 10.1038/223363a0.
4
Hemizygous expression of glucose-6-phosphate dehydrogenase in erythrocytes of heterozygotes for the Lesch-Nyhan syndrome.莱施-奈恩综合征杂合子红细胞中葡萄糖-6-磷酸脱氢酶的半合子表达。
Proc Natl Acad Sci U S A. 1970 Jan;65(1):214-8. doi: 10.1073/pnas.65.1.214.
5
The analysis of malignancy by cell fusion. I. Hybrids between tumour cells and L cell derivatives.通过细胞融合分析恶性肿瘤。I. 肿瘤细胞与L细胞衍生物之间的杂种细胞
J Cell Sci. 1971 May;8(3):659-72. doi: 10.1242/jcs.8.3.659.
6
Fusion of tumour cells with host cells.肿瘤细胞与宿主细胞的融合。
Nat New Biol. 1972 Aug 2;238(83):155-9. doi: 10.1038/newbio238155a0.
7
Positive control of transformed phenotype in hybrids between SV40-transformed and normal human cells.SV40 转化的人类细胞与正常人类细胞杂交中转化表型的阳性控制。
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8
Concordant segregation of the expression of SV40 T antigen and human chromosome 7 in mouse-human hybrid subclones.小鼠 - 人杂交亚克隆中SV40 T抗原表达与人类7号染色体的一致分离。
J Exp Med. 1974 May 1;139(5):1350-3. doi: 10.1084/jem.139.5.1350.
9
Preferential retention of the human chromosome C-7 in human-(thymidine kinase deficient) mouse hybrid cells.人类（胸苷激酶缺陷型）小鼠杂交细胞中人类7号染色体的优先保留。
Exp Cell Res. 1973 Dec;82(2):457-61. doi: 10.1016/0014-4827(73)90366-2.
10
Assignment of the T-antigen gene of simian virus 40 to human chromosome C-7.将猴病毒40的T抗原基因定位于人类C-7染色体。
Proc Natl Acad Sci U S A. 1973 Dec;70(12):3617-20. doi: 10.1073/pnas.70.12.3617.
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